My vote goes for
Four Points on Dewdney. Bland, dull, has a gigantic front parking area on what should have been the start of a revitalized railyards area and is completely suburban in an urban setting. It is absolute garbage for design right in the core.
At least the Royal Hotel is suburban in a suburban setting. It fits in perfectly with Harbour Landing's aesthetic. The McDonald's colouring is tragic, yes and it is quite ugly, but It's Four Points for me.