Yes I noticed Main Meats is no more, and of course Mitchell's Fabrics too.
Even by 2000, when I started exploring the area on my own, there really wasn't much left compared to a decade or so before. Main Meats (in its pre-WRHA location) and Mitchell's, but that's about it beside the soup kitchens, and the bars and cafes in the hotels. Except there was a standalone cafe on the west side of the street, just north of the Bell Hotel... I want to say Empire Cafe? I went in there once, and it looked like they stopped keeping it up around 1960. Good burgers though. The business and the building are now gone.
I'm not sure if Italia Barbers on the ground floor of the McLaren Hotel is still open. I used to go there sometimes, when they were in a building next door before it was demolished. The main guy said he had been cutting hair on Main "all my life," and his barbering certificate was dated 1962. I can't believe the
Free Press or something doesn't do a feature on him. I think this is him (or at least his shop) under the canopy on the left of this photo: