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Originally Posted by Austinlee
It just seems that lead poisoning would be health related and not a breakdown of empathy.
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The C&EN article I linked has a lot of great information on that subject. The upshot is that lead appears to affect brain development in several different ways that collectively increase the risk of aggressive and antisocial behavior. The article mentions interference with the dopamine system (which "controls reward and impulse behavior"), glutamate system ("responsible in part for learning and memory"), and the process of synaptic pruning (which could affect "judgment, impulse control, anticipation of consequences"); also gray matter loss in the ventrolateral prefrontal cortex and the anterior cingulate cortex ("areas known for impulse control, emotional regulation, and decision making"); lowered IQ (which can lead to lower self-esteem, frustration, and delinquent behavior); and inhibition of N-methyl-d-aspartate receptor (NMDAR is "crucial for brain development, learning, and memory processes").
Of course the philosophical point is that there is not necessarily a sharp distinction between "health related" affects and psychological affects when it is the health of the brain we are talking about. But this is getting into the area that makes some people profoundly uncomfortable, if not downright hostile--they perceive a serious challenge to their worldview in the concept that a lot of crime in recent years might be attributable to childhood exposure to a pollutant. That just isn't the sort of story they want to tell about crime--or, perhaps more importantly, the sort of story they want to tell about criminals.