I have had some difficulties to think of a single weird building in Sherbrooke, but here is the most anomalous one I have found.
The CASJB is probably among downtown Sherbrooke's ugliest buildings (it's even worse on
this side). Hopefully, it will eventually be hidden by trees.

By
sherbrooke at 2011-06-25
It was a failed attempt to build something nice. Half of the budget had been cut just before its construction started, so they decided to use painted aluminium instead of chrome.
Saucier + Perrotte