

If you'll permit me ... everything begins with an idea, and focusing on business traffic, examples (from Seattle, as it happens) are upcoming SEA - Begaluru route on AA (Bengaluru being a powerhouse tech centre / Year-round Aer Lingus to Dublin . that city being a major European tech hub): two examples of how a city's economic sectors, if important enough, drive business traffic and make it worthwhile for an airline to negotiate a route, probably O&D, as well. (Airlines 101_)
Vancouver's economy is developing a substantial medical sector.
*(click this and read it if interested)
https://news.gov.bc.ca/releases/2023JEDI0022-000540
In India, the city with the most signicant medical industry > population is Hyderabad. Is an eventual YVR<>HYD possible Even more importantly, can Vancouver diversify its economy to the point of importance? The medical / pharma sector here and in Hyderabad comes to my mind.
https://en.wikipedia.org/wiki/Healthcare_in_Hyderabad
In any event, it seems that, given that business traffic puts butter on their bread, airlines will seek out possible city destinations, mark their economic profile, and try and start a route with a ++yield factor, if there are sufficiently large markets within those sectors. Hey ... you never know