I absolutely do not feel safe biking on Pacific Blvd. Coming from say, somewhere around St. Paul hospital towards the city hall will require that I bike down to the seawall on Hornby. Then take the loop thing up to Cambie bridge to bike through. I mean, that's fine and all, but if I am able to bike more or less straight through Yaletown W-E, it cuts down that part of the commute time by a minimum of 15 minutes. That's not considering the less able individuals who would have a tough time going up the hills on Hornby or maybe even the Cambie bridge loop. The easier you make it for people to bike all around the major parts of Vancouver, the more popular it will be. Currently my suggestion is still to extend the Helmcken road like so:
The red line down along Helmcken would be great to have a dedicated bike lane on. Then it sort of turn itself into Beatty if you follow the residential road. After you reach Beatty, then it has a painted bike lane so that isn't too bad and it connects to Smithe and onto the bridge. I'm going to give this route a try maybe this weekend to test it out.
I biked around Kits through the Burrard bridge recently. Having not been in that part of town for a year or two on my bike, I was very impressed with the upgrades that area received. Now I felt quite safe accessing Kitsilano on my bike and I've been biking that area more and more. In fact, I was able to take a friend of mine, who is very new to biking in Vancouver, around Kits and it was very comfortable.