For us, it's Kenmount Road.
The main intersection in my neighbourhood:
Is approximately 1 kilometre away from this:
Kenmount Road is absolutely disgusting. The Avalon Mall, countless car dealerships, fast food restaurants, strip malls, hotels, banks, offices... many sections of Kenmount Road and its side streets don't even have sidewalks.
The city has a half dozen or more areas that look like the above. And they're growing in size and number all the time.
Then there are the suburban commercial strips. A lesson in poor urban design, but not as offensive as Kenmount Road:
And what is still, in my mind at least, the unrivaled ugliest university in North America - Memorial: