Don't know if it's been mentioned already, but there are several sites for sale that likely would be redeveloped in the future:
- Rainforest Cafe in River North
- Site north of SONU apartments on Fremont (was supposed to be a hotel)
- Vitamin Shoppe on North Ave as well as the four buildings to the south on Clybourn
Also, the City Colleges HQ building on Jackson and Franklin is being converted into a Hilton Garden Inn + Canopy hotel with rooftop bar. Should help add some life to the Loop outside business hours.