Fulton Market is already the equivalent of RiNo in Denver in terms of the vibrancy/density of businesses. It's just developing into a more posh area instead of the hipster hangout that RiNo is - different subculture. The Fulton Market area was pioneered by gourmet-minded restaurateurs on Randolph when the hipsters were still confined to Wicker Park, now it has the fanciest restaurants in the city.
Breweries and distilleries won't locate around there as the space is too expensive to be used for actual production. Landlords are looking for tech companies and Michelin-starred restaurants, not light industrial. Once you go west of Ogden, it's a different story... perfect for breweries/distilleries, art facilities, etc (and many are already there) but the buildings tend to be very big and featureless, so you'll never have the urban character that RiNo does in Denver.
The closest analogy to RiNo in Chicago right now is probably Motor Row, with Motor Row Brewing, Baderbrau, etc but it's looking like that will be developed and dominated by McPier as a Disney-esque conventioneer zone. Huge chain restaurants and clubs for large groups, etc. Here's hoping it retains some creative spark and freshness with rotating murals and so on... but I don't expect McPier to do anything remotely risky.