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Originally Posted by MonkeyRonin
A national border isn't exactly an arbitrary line. There might be common transnational cultural, historic, and geographic traits in the region; but a border still has very real implications - which is why Toronto exists as the "first city" of Canada and not the 1st/2nd city of the Great Lakes.
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Obviously there are implications of these lines but:
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common transnational cultural, historic, and geographic traits in the region
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*and economies
All of this holds much more objective weight, for example regions of Europe and Asia do not start and stop at country lines and it's no different in North America.
Toronto can exist as the first city of both but if we're talking about regions it makes more sense to me to compare by Great Lakes than a term that basically has no meaning in 2019.