London does well supporting the Knights, and the Lightning too I'm pretty sure. And Western is reasonably popular, so I think if the city got on board like they do with their other sports it could work.
Their rock station is quite NFL-heavy, don't know if that's representative of tastes there or if that's standard in non-CFL cities (my other station is Hamilton so obviously lots of CFL talk there). At the very least it doesn't seem like you'd be taking too much from the Ticats although I'm sure there are people who do make the trip.
KW based on size perhaps, and support for the Rangers. But they are closer to Hamilton and increasingly integrated with Toronto, so I don't know.
Here I am daydreaming of a 4-way Southern Ontario Rivalry....