For Cleveland, there are two buildings that qualify imho. The first is the expansion of the
Cleveland Museum of Art - the museum has an amazing collection (free admission except for special exhibits) but for years was a maze of piecemeal additions. Vinoly demolished those and created a massive atrium to connect the original building with the new galleries and office space.
The next is probably more significant as it's being built on what was vast parking lots right in the heart of Downtown Cleveland. The Sherwin Williams World Headquarter building is a handsome but understated tower, but again - it's what it's replacing and filling in a gap on our skyline.