I was talking to a friend who lives in River North about all of the new apartment buildings headed to the area and he brought up a point I hadn't ever considered.
There is a ton of new housing inventory coming to the west side of River North (RiNo; make it happen), like west of Clark, and there are currently no grocery stores in that area.
The only exception is the new Walmart Express at Franklin and Chicago, which has some groceries according to their signage, but I'm sure most River North types would rather eat their own designer dogs than buy foodstuffs from a
Walmart. From what I've been hearing, people end up getting way too much of their staples at the overpriced mini-marts built into their buildings, or they wait until they're completely out of food and then get an uber/zipcar/taxi for a huge Whole Foods trip to stock up.
A Mariano's would probably do killer business if it replaced the Binny's or Office Depot, both of which have out-of-context parking lots. Hopefully the smart people in the grocery industry have realized this already and are making moves to fix this problem.