As a Louisvillian I can say at first I didn't really like it at all. Then the more I looked at it, the more I liked it. Yeah, it is essentially a bunch of boxes stacked on top of each other, but I'd take that over those individual boxes being seperated any day. It distinguishes Louisville from other cities of the same size with similar skylines. With all the new development going on, I wouldn't count it on sticking out so much in the future.
Over at skyscrapercity
Eweezerinc posted this picture that he created that shows the new skyline with Museum Plaza, the arena, and the newly announced Iron quarter (buildings with green and red lights). Doesn't look too bad.