- Originally completed as Detroit Central High School in 1896, the Detroit Junior College began operating out of part of the school in 1916. By 1923 the junior college became the College of the City of Detroit, and by 1926 the high school had moved out of the building, leaving it to the college which would become Wayne State University by 1956.
- The building's clock tower was replaced in 1934, and a new wing along Warren Avenue was added in 1937.
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